2024
Molecular Cell Genome function
Genomic context sensitizes regulatory elements to genetic disruption
84(10), 1842–1854.e7
TSINGHUA UNIVERSITY · SCHOOL OF LIFE SCIENCES
Writing the
genome.
Understanding
life.
We engineer mammalian genomes to explore biological function and the mechanisms of human disease.
GENOME WRITINGSEQUENCE → FUNCTION
CONCEPTUAL SCHEMATIC
Write designed sequences to test how the genome works.
READ. EDIT. WRITE. UNDERSTAND.01 — 03
01 / OUR VISION
From reading life
to rewriting possibilities.
Reading tells us what the genome is.
Writing lets us ask what it can do.
Our lab develops genome writing and editing technologies to investigate complex genomic regions. By building new cellular and animal models, we aim to connect genetic variation with biological mechanisms.
The questions we ask02 / RESEARCH
Three perspectives.
One genome.
01
Write
genomes.
Building the tools to rewrite mammalian DNA at larger scales.
Genome engineering · Synthetic genomics02
Understand
function.
Exploring how complex genomic regions shape biological function.
Regulation · Genomic context03
Model
disease.
Connecting genomic changes with mechanisms of human disease.
Cell models · Animal models03 / SELECTED WORK
Ideas into evidence.
MAMMALIAN GENOME WRITING
NATIVE LOCUS
CONCEPTUAL SCHEMATIC↓ENGINEERED LOCUS
NATURE 2023
Mouse genome rewriting and tailoring of three important disease loci
Genome writing extends the scale at which we can construct and investigate disease-associated genomic regions.
Read the paper↗
2017
Science Genome writing
Engineering the ribosomal DNA in a megabase synthetic chromosome
355(6329), eaaf3981
05 / NEWS